Spills can happen during a substance's storage, it's transfer or transport, or during use as leaks.

Here are a few tips in preventing actual spills:

• substances should be stored on a strong shelf and aptly designed storage areas that minimize breakage and tipping
• larger containers should be stored closer to the floor
• containers on shelves should be placed further away from the edge to prevent incidents of falling
• storage shelves with lips also reduce the danger of falling
• regular inspection for integrity of the containers should be done
• usage of carts in transporting or moving containers
• using pumps in transferring substances from a container to another
• providing spill containment to capture any leaks. 
• reducing clutter and unnecessary materials
• eliminating trip hazards and other obstructions in the workplace
• preparing all necessary equipment before starting work
• check for any holes or leaks for transfer equipment like hoses, pipes, and valves